Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC021
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-19 08:31
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT MADOPAR A 250MG 3X1\2 PK MERZ 100MG 3X1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 4, 'TP': 37, 'FP': 26}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.444
timePerCircleCoV 0.15138
timePerCircleSlope 0.0228515
meanError 4.10548
tremorFreq 6.83594
tremorRelPower 31.4525
tremorGyroAmpMean 0.0261501
tremorGyroAmpSlope 0.000948007
tremorGyroAmpCoV 0.414718
tremorCoordAmpMean 0.0611248
tremorCoordAmpSlope 0.00518355
tremorCoordAmpCoV 0.851327
tremorAccAmpMean 0.045029
tremorAccAmpSlope -0.000457064
tremorAccAmpCoV 0.370103
tremorPcRelVar 0.653174
tremorPcX 0.960318
tremorPcY -0.278909

Circle Segment 1

Duration 12.68 s, Accuracy Estimate 3.677 (lower is better)

Circle Segment 2

Duration 10.68 s, Accuracy Estimate 3.937 (lower is better)

Circle Segment 3

Duration 9.0 s, Accuracy Estimate 4.133 (lower is better)

Circle Segment 4

Duration 15.04 s, Accuracy Estimate 4.177 (lower is better)

Circle Segment 5

Duration 10.96 s, Accuracy Estimate 3.618 (lower is better)

Circle Segment 6

Duration 12.56 s, Accuracy Estimate 4.44 (lower is better)

Circle Segment 7

Duration 13.0 s, Accuracy Estimate 4.044 (lower is better)

Circle Segment 8

Duration 12.28 s, Accuracy Estimate 4.033 (lower is better)

Circle Segment 9

Duration 15.12 s, Accuracy Estimate 4.263 (lower is better)

Circle Segment 10

Duration 13.12 s, Accuracy Estimate 4.733 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 37.595
timePerSpiralCoV 0.178903
timePerSpiralSlope 0.0519446
meanError 3.83475
tremorFreq 6.83594
tremorRelPower 26.4815
tremorGyroAmpMean 0.0244522
tremorGyroAmpSlope -0.000413494
tremorGyroAmpCoV 0.355357
tremorCoordAmpMean 0.046508
tremorCoordAmpSlope -0.000470015
tremorCoordAmpCoV 0.316792
tremorAccAmpMean 0.0398735
tremorAccAmpSlope -0.000307075
tremorAccAmpCoV 0.338559
tremorPcRelVar 0.613014
tremorPcX 0.675412
tremorPcY 0.737441

Spiral Segment 1

Duration 23.24 s, Accuracy Estimate 3.745 (lower is better)

Spiral Segment 2

Duration 39.08 s, Accuracy Estimate 3.746 (lower is better)

Spiral Segment 3

Duration 35.76 s, Accuracy Estimate 3.896 (lower is better)

Spiral Segment 4

Duration 42.28 s, Accuracy Estimate 3.948 (lower is better)

Spiral Segment 5

Duration 34.08 s, Accuracy Estimate 3.816 (lower is better)

Spiral Segment 6

Duration 39.68 s, Accuracy Estimate 3.787 (lower is better)

Spiral Segment 7

Duration 43.96 s, Accuracy Estimate 3.836 (lower is better)

Spiral Segment 8

Duration 42.68 s, Accuracy Estimate 3.905 (lower is better)

Elel

eDurationMean 0.638293
eDurationStd 0.118172
eDurationStdnorm 0.185137
eDurationMedian 0.62
eDurationQuartdelta 0.14375
eDurationQuartdeltanorm 0.231855
eDurationKurt 3.23514
eDurationTrenddiff 0.015
eDurationTrendratio 1.02459
eWidthMean 5.62456
eWidthStd 1.43495
eWidthStdnorm 0.255123
eWidthMedian 5.265
eWidthQuartdelta 1.90125
eWidthQuartdeltanorm 0.361111
eWidthKurt 3.02923
eWidthTrenddiff -0.468
eWidthTrendratio 0.918367
eHeightMean 8.98902
eHeightStd 1.40957
eHeightStdnorm 0.15681
eHeightMedian 9.36
eHeightQuartdelta 1.49175
eHeightQuartdeltanorm 0.159375
eHeightKurt 2.59263
eHeightTrenddiff 0.2925
eHeightTrendratio 1.03185
eAspectMean 0.623229
eAspectStd 0.110787
eAspectStdnorm 0.177762
eAspectMedian 0.6
eAspectQuartdelta 0.127116
eAspectQuartdeltanorm 0.21186
eAspectKurt 4.21745
eAspectTrenddiff -0.0619249
eAspectTrendratio 0.902091
eSlantMean 0.183597
eSlantStd 0.126044
eSlantStdnorm 0.686527
eSlantMedian 0.164557
eSlantQuartdelta 0.082423
eSlantQuartdeltanorm 0.500878
eSlantKurt 3.85452
eSlantTrenddiff -0.00523376
eRtopMean 0.781314
eRtopStd 0.0786778
eRtopStdnorm 0.100699
eRtopMedian 0.78125
eRtopQuartdelta 0.120578
eRtopQuartdeltanorm 0.15434
eRtopKurt 2.22475
eRtopTrenddiff 0.000319183
eRbotMean 0.497797
eRbotStd 0.157735
eRbotStdnorm 0.316867
eRbotMedian 0.470588
eRbotQuartdelta 0.181743
eRbotQuartdeltanorm 0.386205
eRbotKurt 5.04064
eRbotTrenddiff -0.0256456
eRrightMean 0.88845
eRrightStd 0.0464946
eRrightStdnorm 0.0523322
eRrightMedian 0.890244
eRrightQuartdelta 0.0633802
eRrightQuartdeltanorm 0.0711942
eRrightKurt 2.6123
eRrightTrenddiff -0.0179736
eRleftMean 0.25519
eRleftStd 0.0857148
eRleftStdnorm 0.335886
eRleftMedian 0.253968
eRleftQuartdelta 0.0777464
eRleftQuartdeltanorm 0.306126
eRleftKurt 8.3205
eRleftTrenddiff -0.000879399
lDurationMean 0.878
lDurationStd 0.139251
lDurationStdnorm 0.1586
lDurationMedian 0.8925
lDurationQuartdelta 0.195
lDurationQuartdeltanorm 0.218487
lDurationKurt 2.46561
lDurationTrenddiff 0.1575
lDurationTrendratio 1.20128
lWidthMean 9.75488
lWidthStd 1.3959
lWidthStdnorm 0.143098
lWidthMedian 9.6525
lWidthQuartdelta 1.8135
lWidthQuartdeltanorm 0.187879
lWidthKurt 4.71325
lWidthTrenddiff -0.6435
lWidthTrendratio 0.935294
lHeightMean 18.9716
lHeightStd 1.95967
lHeightStdnorm 0.103295
lHeightMedian 18.5445
lHeightQuartdelta 2.34
lHeightQuartdeltanorm 0.126183
lHeightKurt 3.08162
lHeightTrenddiff -0.702
lHeightTrendratio 0.963415
lAspectMean 0.517712
lAspectStd 0.0829324
lAspectStdnorm 0.16019
lAspectMedian 0.51564
lAspectQuartdelta 0.0845337
lAspectQuartdeltanorm 0.163939
lAspectKurt 3.86152
lAspectTrenddiff -0.0315305
lAspectTrendratio 0.940101
lSlantMean 0.316589
lSlantStd 0.0709016
lSlantStdnorm 0.223955
lSlantMedian 0.317896
lSlantQuartdelta 0.0683871
lSlantQuartdeltanorm 0.215124
lSlantKurt 4.05927
lSlantTrenddiff -0.0323821
lRtopMean 0.916776
lRtopStd 0.0363563
lRtopStdnorm 0.0396567
lRtopMedian 0.915694
lRtopQuartdelta 0.0517647
lRtopQuartdeltanorm 0.0565305
lRtopKurt 5.25943
lRtopTrenddiff 0.000823734
lRbotMean 0.306687
lRbotStd 0.0946215
lRbotStdnorm 0.308528
lRbotMedian 0.312548
lRbotQuartdelta 0.122263
lRbotQuartdeltanorm 0.391182
lRbotKurt 3.03786
lRbotTrenddiff 0.00642472
lRrightMean 0.944687
lRrightStd 0.0349525
lRrightStdnorm 0.036999
lRrightMedian 0.950486
lRrightQuartdelta 0.0349589
lRrightQuartdeltanorm 0.03678
lRrightKurt 5.12161
lRrightTrenddiff -0.00740571
lRleftMean 0.156619
lRleftStd 0.0545274
lRleftStdnorm 0.348152
lRleftMedian 0.160752
lRleftQuartdelta 0.076894
lRleftQuartdeltanorm 0.47834
lRleftKurt 2.93047
lRleftTrenddiff -0.00154823

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.701827
sumTouchScores 14.0365
meanMovementTime 0.850526
numTouches 20
undershootPercentage 0
overshootPercentage 20

FITTS Long Modified

meanTouchScore 0.918142
sumTouchScores 14.6903
meanMovementTime 1.15967
numTouches 16
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 35.584
timePerZigzagCoV 0.169995
timePerZigzagSlope 0.060589
meanError 1.95527
tremorFreq 6.34766
tremorRelPower 28.4617
tremorGyroAmpMean 0.0277632
tremorGyroAmpSlope 0.000267783
tremorGyroAmpCoV 0.344708
tremorCoordAmpMean 0.0796163
tremorCoordAmpSlope 0.000151206
tremorCoordAmpCoV 0.715155
tremorAccAmpMean 0.064378
tremorAccAmpSlope -0.000167854
tremorAccAmpCoV 0.187542
tremorPcRelVar 0.814741
tremorPcX -0.18628
tremorPcY 0.982497

ZigZag Segment 1

Duration 28.2 s, Accuracy Estimate 2.339 (lower is better)

ZigZag Segment 2

Duration 40.32 s, Accuracy Estimate 1.737 (lower is better)

ZigZag Segment 3

Duration 29.88 s, Accuracy Estimate 2.042 (lower is better)

ZigZag Segment 4

Duration 40.76 s, Accuracy Estimate 1.781 (lower is better)

ZigZag Segment 5

Duration 38.76 s, Accuracy Estimate 1.877 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.104
timePerZigzagCoV 0.118088
timePerZigzagSlope -0.0318494
zigzagHeightMean 51.2279
zigzagHeightCoV 0.0752474
zigzagHeightSlope -0.0450461
meanError 0.0261508
tremorFreq 6.73828
tremorRelPower 26.7606
tremorGyroAmpMean 0.0322412
tremorGyroAmpSlope -0.000720733
tremorGyroAmpCoV 0.327049
tremorCoordAmpMean 0.0992655
tremorCoordAmpSlope -0.00710628
tremorCoordAmpCoV 0.710854
tremorAccAmpMean 0.0529811
tremorAccAmpSlope -0.0019631
tremorAccAmpCoV 0.317561
tremorPcRelVar 0.77895
tremorPcX -0.0797575
tremorPcY -0.996814

ZigZag Offset Segment 1

Duration 20.8 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 2

Duration 24.44 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 24.84 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 4

Duration 21.88 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 18.56 s, Accuracy Estimate 0.032 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.46931556709882294}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.33044866877108237}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}